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A case of Ménétrier's disease without Helicobacter pylori infection
Author(s) -
Endo Takao,
Arimura Yoshiaki,
Adachi Yasushi,
Mita Hiroaki,
Yamashita Kentaro,
Yamamoto Hiroyuki,
Shinomura Yasuhisa,
Ishii Yoshifumi
Publication year - 2012
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.2012.01242.x
Subject(s) - foveolar cell , medicine , helicobacter pylori , gastroenterology , gastritis , etiology , stomach , hyperplasia , gastric mucosa , pathology
Ménétrier's disease (MD) is a rare, acquired, premalignant disorder of the stomach characterized by enlarged gastric folds with foveolar hyperplasia, the phenotype of antralization of gastric glands, hypochlorhydria and hypoproteinemia. The etiology of MD is unknown, but both increased signaling by transforming growth factor‐α and infection with Helicobacter pylori ( H. pylori ) have been implicated. Here, a case involving 70‐year‐old man who lost weight after developing anorexia and diarrhea is reported. He was diagnosed as MD without H. pylori infection, and in spite of intensive care, he died 40 days after admission. An autopsy confirmed MD. Immunohistochemistry revealed overexpression of transforming growth factor‐α in the foveolar region of the gastric mucosa. The autopsy also distinguished this H. pylori ‐negative MD from hyperplastic polyp of the stomach, which is important in clarifying the entity of H. pylori ‐negative MD.