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CONTACT ULTRA‐HIGH MAGNIFYING ENDOSCOPY CAN DIFFERENTIATE SQUAMOUS CELL CARCINOMA FROM NON‐CANCEROUS SQUAMOUS CELLS IN THE ESOPHAGUS: TWO CASES OF SUPERFICIAL ESOPHAGEAL CARCINOMA
Author(s) -
Kaise Mitsuru,
Goda Kenich,
Yoshida Yukinaga,
Yonezawa Jin,
Kato Masayuki,
Tajiri Hisao
Publication year - 2007
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.2007.00724.x
Subject(s) - medicine , pathology , esophagus , ex vivo , in vivo , endoscopy , endoscopic mucosal resection , carcinoma , basal cell , radiology , biology , microbiology and biotechnology
Endocytoscopy, a type of contact ultra‐high magnifying endoscopy, enables in vivo observation of cells in the gastrointestinal tract. To test its clinical relevance, endocytoscopy was conducted on ex vivo specimens from two cases of superficial esophageal carcinoma that were resected by endoscopic mucosal resection (EMR). Using a catheter‐type system with ×450 magnification, endocytoscopic observation was performed on small areas of cancerous and non‐cancerous squamous cells, which were subsequently retrieved for pathological examination on horizontal sections. In both cases, endocytoscopy identified non‐cancerous areas as cells with sparsely distributed round nuclei and a low nucleus‐cytoplasm (NC) ratio, which correlated well with histological sections. Similarly, the endocytoscopy correlated well with histological sections of cancerous areas and identified cells with densely distributed irregular nuclei with a high NC ratio. In conclusion, the high correlation between histological and endocytoscopic identification of cancerous and non‐cancerous lesions may enable endocytoscopic diagnosis that is of comparable accuracy to the current pathological methodology. A prospective in vivo study is required to confirm the evidence.