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FAMILY STUDY SHOWING A CLOSE ASSOCIATION OF HLA DPB1*0202/0901 WITH ULCERATIVE COLITIS
Author(s) -
Furukawa Hiroo,
Morichi Hisako,
Moriyasu Takayuki,
Nishimura Tomomi,
Ohmori Yasushi,
Hiratsuka Takuya,
Saiga Tatsuyoshi
Publication year - 2006
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.2006.00630.x
Subject(s) - haplotype , human leukocyte antigen , major histocompatibility complex , ulcerative colitis , immunology , medicine , genetics , genetic predisposition , allele , antigen , biology , gene , disease , pathology
Genetic disposition and environmental factors are closely related to the occurrence of ulcerative colitis (UC). The HLA haplotypes of major histocompatibility complex (MHC) Class II are considered to be the most important genetic factors in UC. The current report focuses on the genetic human leukocyte antigen (HLA) of a family in which UC crises have occurred in five of six members with identical MHC Class II haplotypes. Haplotypes A24/26 (A24/‐), BW4/6 (BW4/‐) and DQ1/3 (DQ1/‐) were found in all six members of the family. In DNA typing, characteristic loci common to this family were seen in DRB11502 and DQB10601. From the genetic investigation of this family, we concluded that HLA haplotypes are the most important genetic factors in the occurrence of UC.