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FREQUENT K‐RAS MUTATIONS AMONG LATERALLY SPREADING TUMORS WITH GRANULAR COMPONENTS AND THEIR SIGNIFICANCE FOR RECTAL CARCINOMAS
Author(s) -
Yokoyama Yuichi,
Tamura Satoru,
Onishi Saburo
Publication year - 2005
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.2005.00465.x
Subject(s) - rectum , medicine , colorectal cancer , mutation , pathology , cancer research , gene , cancer , biology , genetics
Background: To clarify the genetic characteristics of superficial‐type colorectal tumors, we investigated gene mutations of K‐ras codon 12 of superficial‐type colorectal tumors. Methods: We examined the endoscopic appearance of 72 specimens for K‐ras mutations. Results: Laterally spreading tumors with granular components had a high incidence of K‐ras mutations (68%). As for tumor locations, the K‐ras mutation was detected in 13/19 (68.4%) tumors of the rectum, 10/36 (27.8%) tumors of the proximal colon and in 5/17 (29.4%) tumors of the distal colon. Conclusion: ;Our results suggest that superficial‐type tumors with granular components and rectal ones may have a different genetic pathway for tumor progression compared with those without granular components and colonic ones, respectively.