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Amyloid Colitis: Successful Treatment with Colchicine Therapy
Author(s) -
HIRASAKI Shoji,
KOIDE Norio,
NAKAGAWA Kazuhiko,
SHIMA Yasuo,
OGAWA Hiromichi,
UJIKE Kozo,
OKADA Hiroyuki,
MIZUNO Motowo,
UKIDA Minora,
TSUJI Takao
Publication year - 1998
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1998.tb00561.x
Subject(s) - medicine , amyloidosis , lamina propria , pathology , colchicine , amyloid (mycology) , submucosa , gastroenterology , epithelium
We treated a case of systemic amyloidosis which exhibited clinical symptoms of amyloid colitis. The patient was a 61‐year‐old man with bloody diarrhea. Endoscopic examination revealed multiple erosions and small ulcerations with bleeding, bloodshot mucosa and loss of the normal vascular pattern in the transverse colon. Histological examination revealed infiltration by inflammatory cells in the lamina propria, and congo red dye showed deposition of amyloid material in the submucosa and in the walls of blood vessels. Endoscopic examination of the upper digestive tract revealed an erosive reddish area in the antrum, and a biopsy specimen from this lesion showed amyloid material histologically. With ultrasonic cardiography, amyloid deposition was suspected in the heart. Therefore, the patient was diagnosed with systemic amyloidosis. We started the administration of colchicine 1 mg/day and commenced follow‐up endoscopy. The patient's diarrhea was improved after the administration of colchicine, and mucosal lesions of the transverse colon were improved endoscopically. Moreover, amyloid deposition in the cardiac wall seemed to have disappeared on ultrasonic cardiography. From these observations, colchicine therapy was considered to be an effective treatment for systemic amyloidosis in the present case.