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A Study of the Rate of Superficial Cancer Progressing to Advanced Cancer of the Colon and Rectum
Author(s) -
SAITO Kenichi,
OGAWA Akira,
OHKI Ichiro
Publication year - 1996
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1996.tb00439.x
Subject(s) - medicine , colorectal cancer , cancer , rectum , pathology
In order to clarify the rate of superficial cancer developing into colorectal cancer histologically, we examined horizontal growth type cancer in the residual mucosa of 68 samples with submucosal (sm) cancer, 91 with cancer with invasion of the muscularis propria (mp) and 311 with invasion deeper than the subserosa (ss). Among 68 samples of sm cancer, residual mucosa persisted in 65 (95.6%) and horizontal growth type cancer was found in 17 (26.2%). There was no significant difference in size between the horizontal and non‐horizontal growth type cancers. Among 91 samples of mp cancer, residual mucosa persisted in 15 (15.5%), horizontal growth type cancer was found in five (33.3%), and the latter were significantly smaller than non‐horizontal growth type cancers (p< 0.05). Among 311 samples of ss cancer, residual mucosa persisted in 12 (3.9%) and horizontal growth was found in six (50.0%). In cancer with invasion deeper than the ss layer, malignant tissue is generally lost from the mucosa, such that the rates may not reflect the actual incidence. The rates of progression from superficial to sm cancer (26.2%) and mp cancer (33.3%) may be close to the present rate of superficial cancer developing into colorectal cancer. We conclude that the rate of superficial cancer developing into invasive cancer is at least 26.2%, and that superficial type cancers have a strong tendency to invade the mp even when smaller than protruded type cancers. It may be useful to focus on horizontal growth type cancers to elucidate the growth and development of colorectal cancer.