Premium
Gastric Emptying and Gastroesophageal Reflux in Patients Fed via Percutaneous Endoscopic Gastrostomy: Effects of Erythromycin
Author(s) -
OGAWA Shigehiko,
KOICHI Katsuyuki,
TAKIMOTO Hiroaki,
WAKABAYASHI Tokio,
KAWAURA Yukimitsu,
TOFUKU Yohei
Publication year - 1996
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1996.tb00425.x
Subject(s) - medicine , gastric emptying , percutaneous endoscopic gastrostomy , reflux , gastroenterology , erythromycin , prokinetic agent , esophageal ph monitoring , motilin , peg ratio , placebo , stomach , antibiotics , gerd , disease , pathology , alternative medicine , finance , microbiology and biotechnology , economics , biology
Percutaneous endoscopic gastrostomy (PEG) has been suggested to affect gastric emptying. The aims of this prospective study were to examine the effects of erythromycin, known to act as a motilin agonist, on gastroesophageal motility in nine patients fed via PEG tubes and nine fed via nasogastric tubes. The gastric emptying time and gastroesophageal reflux index were simultaneously measured in each patient after the intravenous administration of erythromycin (200 mg) or a placebo on different days, using a radioisotopic method. The alteration of gastric emptying time produced by intravenous erythromycin in the PEG group was smaller than that in the nasogastric group (p<0.05). However, gastroesophageal reflux indices in the two groups were similar. We conclude that PEG may impair gastric emptying subclinically without affecting gastroesophageal reflux.