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Effect of Acetyl Salicylic Acid and Cetraxate on Human Gastric Mucosal Blood Flow: Clinical Application of Laser Doppler Measurement
Author(s) -
USUI Hiroko
Publication year - 1995
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1995.tb00393.x
Subject(s) - salicylic acid , medicine , curvatures of the stomach , antrum , blood flow , gastroenterology , stomach , chemistry , biochemistry
The effects of acetyl salicylic acid and cetraxate on gastric mucosal blood flow (GMBF) were examined in human subjects. GMBF was determined endoscopically using a laser Doppler flowmeter. The normal value in 16 adults ranged from 1.7 ± 0.8 volts (mean ± SD) at the lesser curvature of the antrum to 3.72 ± 0.79 volts at the greater curvature of the body. In four normal volunteers, the time course of GMBF was measured after the oral intake of 0.5 g acetyl salicylic acid with or without cetraxate. GMBF was significantly lower after intake of acetyl salicylic acid at 15 min at the lesser curvature of the body (3.6 ± 1.0 to 2.3 ± 0.7, P<0.05) and at 20 min at the lesser curvature of the antrum (2.7 ± 0.6 to 1.4 ± 0.2, P<0.05), as compared with the values at 5 min. This adverse effect of acetyl salicylic acid on GMBF was inhibited by concomitant administration of 0.8 g cetraxate. It was concluded that cetraxate prevented the acetyl salicylic acid induced decrease in GMBF.