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Adhesive Effect of Ecabet Sodium in a Porcine Gastric Leer Model
Author(s) -
NAKADA Shuji,
KAGAMI Akihiko,
IWASAKI Masafumi,
MOCHIZUKI Keiko,
KINOSHITA Tomoko,
NISHIDE Ryoichi,
TANAMURA Akira,
USUI Toshiro,
ISHIKI Motoo,
TANAKA Yoshihiro,
TAKEUCHI Yukihiro,
SUZUKI Hiroaki,
MOCHIZUKI Seibu
Publication year - 1995
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1995.tb00392.x
Subject(s) - sucralfate , medicine , antiulcer drug , gastric mucosa , gastroenterology , adhesion , stomach , gastric content , drug , pharmacology , chemistry , organic chemistry
Protection of the gastric mucosa, based on its high affinity for mucosal lesions, has been reported as one of the antiulcer effects of ecabet sodium. We investigated the adhesive effect of this drug on mucosal lesions in a porcine gastric ulcer model (freshly isolated stomach) and on human mucosal lesions resulting from endoscopic gastric mucosal resection (EMR) and polypectomy. After ulcer lesions had been induced by EMR in the isolated porcine stomach, ecabet sodium and sucralfate suspensions were applied. After washing with citrate buffer, at a pH of 1, 3 or 5, the adhesion of each drug to the gastric mucosa was measured. At pH 1, both drugs showed satisfactory adhesion to the ulcer lesions. When the acidity of the ulcer surfaces was decreased to pH 3 and then to pH 5, the adhesion of sucralfate showed a marked decrease (100%→31→% 13%). while that of ecabet sodium showed only a slight decrease (100%→75%→64%). Futhermore, the activity of thrombin in the ecabet sodium suspension remained high at pH 1, 3 and 5. Since the ecabet sodium suspension produced a satisfactory covering effect on gastric mucosal lesions and this effect was maintained even at low acidity, this drug is considered suitable for endoscopic directsprinkling therapy for gastric mucosal lesions.