Endoscopy and Crohn's Disease: Endoscopic Approach to the Pathogenesis of Crohn's Disease | Zendy

ASAKURA Hitoshi | Zendy; HONMA Terasu | Zendy; NARISAWA Rintaro | Zendy

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Endoscopy and Crohn's Disease: Endoscopic Approach to the Pathogenesis of Crohn's Disease

Author(s) -

ASAKURA Hitoshi,

HONMA Terasu,

NARISAWA Rintaro

Publication year - 1994

Publication title -

digestive endoscopy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.5

H-Index - 56

eISSN - 1443-1661

pISSN - 0915-5635

DOI - 10.1111/j.1443-1661.1994.tb00687.x

Subject(s) - medicine , crohn's disease , disease , endoscopy , etiology , pathogenesis , crohn disease , biopsy , vasculitis , lesion , mucosal lesions , gastroenterology , pathology

This review describes endoscopic and histopathological findings in Crohn's disease with reference to its pathogenesis. The number of patients with Crohn's disease has markedly and rapidly increased during the last 10 years in Japan. Minute lesions such as aphthoid ulcers as an early lesion in Crohn's disease were at first discussed endoscopically and histopathologically. Recent advances concerning the mechanism of how aphthoid ulcers may occur revealed that they are induced by mucosal ischemia due to vasculitis. Longitudinal ulcers and cobblestone appearance were observed only in advanced Crohn's disease. Finally, the etiology of Crohn's disease was reviewed from the viewpoint of infectious agents and immunological abnormalities which were clarified from the study of endoscopic biopsy specimens.

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