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Gastric Mucosal Injury by Transendoscopic Compressed Air Delivery of Powdered NaCl, KCl or NSAIDs in Dogs
Author(s) -
HOSHINO Teruo,
ENDO Toru,
KUSAKARI Koji,
ISHIDA Masashi
Publication year - 1993
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1993.tb00642.x
Subject(s) - sucralfate , medicine , gastric mucosa , aspirin , gastroenterology , gastritis , diclofenac sodium , diclofenac , stomach , antrum , pharmacology
Seven kinds of NaCl, KCl, aspirin, indomethacin, diclofenac sodium, lactose and sucralfate, all in powder form, were administered by an endoscopic compressed air drug delivery system, in doses of 25 mg each, to specific target sites of the gastric mucosa of dogs. Changes in the gastric mucosa were endoscopically observed. When NaCl, KCl and aspirin were administered, mucosal lesions were observed but were limited to the target site of the gastric mucosa. Indomethacin (2/7 dogs) and diclofenac sodium (3/7 dogs) were observed to induce superficial gastritis at the pyloric antrum but did not induce gastric mucosal lesions at the target sites. In addition, no lesions were induced by either lactose or sucralfate. In the present study, it was possible to induce an experimental gastric mucosal lesion at the target site of the gastric mucosa by administration of a small amount of powdered drugs via an endoscope and compressed air. The administration of the powdered drugs by endoscopy is useful for investigation of the direct effects of drugs such as aspirin, NaCl and KCl on the gastric mucosa. Furthermore, this method is applicable in order to investigate and develop drugs (such as sucralfate) for direct therapy of gastric mucosal lesions.