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Trans‐endoscopic Drug Propulsion Therapy
Author(s) -
HOSHINO Teruo,
OZEKI Arata,
KUSAKARI Kouji,
ISHIDA Masashi,
Barron J. Patrick
Publication year - 1993
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1993.tb00621.x
Subject(s) - medicine , drug delivery , drug , sucralfate , in vivo , pill , propulsion , penetration (warfare) , endoscope , hemostasis , biomedical engineering , pharmacology , surgery , nanotechnology , aerospace engineering , materials science , microbiology and biotechnology , operations research , engineering , biology
A new endoscopic drug delivery system was developed by the authors. This system allows for drugs in the form of solid pills, grains, and powders to be delivered to target sites using an air gun propulsion system. Following initial in vitro trials, in vivo studies were performed on dogs, using steel pills, grains of activated carbon, and of sucralfate, and bovine thrombin powder. The depth of pill penetration increased linearly with increases in air pressure. The extent of grain distribution increased in relation to the distance from the tip of the endoscope to the target. Propulsion pressures over certain thresholds (which varied according to the materials propelled) produced bleeding in the stomach wall, but no clearly observed ulceration was observed at any of the pressures tested. The targets were adequately covered by the grains and powder. This drug delivery system shows promise for the treatment of malignant lesions, ulcers and bleeding, and other applications where localized delivery, of drugs is indicated.