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A Case of Funnel Liver Induced by Dimethylformamide
Author(s) -
KAKIO Takeshi,
UKIDA Minoru,
ITO Toshio,
YAMAMOTO Kazuhide,
TANIMIZU Masahito,
MIZUTAMARI Koukichi,
MORIMOTO Youichi,
KOBASHI Haruhiko,
MATSUO Ryuichi,
SAKAI Nobuyuki,
MIYAMOTO Rieko,
YAMADA Gotaro,
TSUJI Takao
Publication year - 1992
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1992.tb00229.x
Subject(s) - medicine , liver injury , liver biopsy , laparoscopy , capsule , indocyanine green , pathology , biopsy , liver tissue , h&e stain , necrosis , staining , radiology , biology , botany
The laparoscopic and histological findings of a patient suffering from dimethylformamide (DMF) intoxication are discussed. A 20‐year‐old man was admitted to our department for further evaluation of a liver injury. A laparoscopy revealed that the liver was markedly deformed by a combination of depressions and protuberances, and this finding was compatible with the funnel liver reported by H. Kalk. After an intravenous injection of high dose indocyanine green, broad whitish depressions appeared as a non‐staining area and surrounding protuberances were stained a dark green color. A biopsy specimen taken from the site of the depression showed massive hepatic necrosis and a scar under the capsule. The histological diagnosis was a convalescent stage of toxic liver injury. The present report is apparently the first to consider the detailed laparoscopic findings of a liver injury induced by DMF.