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Laparoscopic Follow‐up of Asymptomatic Primary Biliary Cirrhosis with Negative Anti‐mitochondrial Antibody
Author(s) -
WATANABE Makoto,
UCHIDA Yasushi,
ADACHI Kyoichi,
KOHGE Naruaki,
ONO Naomi,
FUKUMOTO Shiro
Publication year - 1992
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1992.tb00226.x
Subject(s) - medicine , asymptomatic , primary biliary cirrhosis , ursodeoxycholic acid , cirrhosis , laparoscopy , liver biopsy , gastroenterology , biopsy , antibody , radiology , immunology
The case of a 59 year‐old female with asymptomatic primary biliary cirrhosis with negative anti‐mitochondrial antibody is presented. According to the results of the first laparoscopy and liver biopsy, reddish patch was observed but chronic non‐suppurative destructive cholangitis could not histologically be confirmed. A follow‐up laparoscopy with liver biopsy conducted 39 months after the first laparoscopy revealed progress in the laparoscopic findings, i. e. a focal appearance of mesh‐like white marking and undulation, when chronic non‐suppurative destructive cholangitis was histologically demonstrated. Following the diagnosis of primary biliary cirrhosis, ursodeoxycholic acid treatment was begun, and the patient's serum levels of transaminases and biliary tract enzymes showed a rapid improvement. The importance of a laparoscopy with liver biopsy for the diagnosis of asymptomatic primary biliary cirrhosis in a case with negative anti‐mitochondrial antibody is emphasized, and the follow‐up of such a case discussed.