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A Case of Cronkhite–Canada Syndrome—With Special Reference to Magnifying Endoscopic Observation of Polyps and Coeliac Angiographic Findings—
Author(s) -
MAKIYAMA Kazuya,
IWANAGA Seima,
KATSUMATA Tatsuya,
FUKAUMI Atsushi,
MUTA Kouki,
ITSUNO Minoru,
UMENE Yoshihiko,
SENJU Masahiro,
MURATA Ikuo,
HARA Kohei
Publication year - 1992
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1992.tb00110.x
Subject(s) - medicine , hyperaemia , gastroenterology , endoscope , pathology , radiology , blood flow
The Cronkhite‐Canada syndrome was diagnosed in a 62 year‐old male in whom the gastrointestinal polyposis and ectodermal change disappeared after treatment with corticosteroids and albumin infusions. The major pathophysiologv of this syndrome is gastrointestinal polyposis. The polyps were examined in detail using a magnifying endoscope and then by spraying methylene blue onto the mucosa. It was shown that the polyps were formed by groups of intestinal glands each dilated by hyperaemia and oedema. Destruction of the dilated glands and opening of a pit at the central region were also observed. These changes were associated with secretion from the pit and it is suggested that this is the mechanism for the protein leakage. Angiographic studies confirmed our previous finding that the coeliac and mesenteric arteries are dilated in the Cronkhite‐Canada syndrome but a follow‐up study showed that this is reversible once the mucosal lesions have resolved in response to treatment.