Premium
Helicobacter pylori Distribution in Human Gastric Mucosa with Chronic, Atrophic Gastritis
Author(s) -
KOHLI Yoshihiro,
KATO Takuji,
ITO Shigeji,
IWAI Makoto,
HATA Masanori,
YAMAZAKI Yukinao
Publication year - 1992
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1992.tb00102.x
Subject(s) - atrophic gastritis , atrophy , medicine , intestinal metaplasia , helicobacter pylori , gastric mucosa , gastroenterology , gastritis , stomach , chronic gastritis , helicobacter , pathology
In animals a continuous administration of 0.02% NH 3 induced by Helicobacter pylori is well known to lead to glandular atrophy of the gastric mucosa and to induce active, chronic gastritis. In addition, this organism has been demonstrated to be closely related to chronic, active gastritis in man. In the present study, a phenol red dye spraying endoscopy was re‐formed in 54 patients with chronic, atrophic gastritis to elucidate the distribution of this organism in the human gastric mucosa, and to clarify the relationship between its presence and chronic, atrophic gastritis. No red color reaction was found in 12 (92.3%) of 13 patients who had no glandular atrophy of the stomach. A diffuse and/or regional red color reaction was most prominent in those with slight degrees of glandular atrophy of the stomach, and was less striking in those with severe atrophy of the gastric mucosa associated with intestinal metaplasia. In addition, no red color reaction was visible in 14 (87.5%) of 16 patients showing a C 0 pattern in the fundic‐pyloric border classification, whereas a diffuse and/or regional red color reaction was observed in over 75% of patients showing C 1 ‐O 2 patterns and less frequently in those with an O 3 Pattern. These data suggest a positive relationship between the presence of this organism and chronic, atrophic gastritis in man.