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A Case of Pachydermoperiostosis with Watery Diarrhea, Giant Gastri Rugae, and Endocrine Disorder
Author(s) -
KISHIDA Keiko,
FUKUMOTO Shiro,
WATANABE Makoto,
ADACHI Kyoichi,
AMANO Kazutoshi,
OHTANI Miyako,
ARIMA Noriyuki,
IKEDA Satoru,
SHIMADA Yoshihiro
Publication year - 1991
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1991.tb00325.x
Subject(s) - medicine , achlorhydria , diarrhea , endocrine system , gastrointestinal tract , gastroenterology , hyperplasia , stomach , pathology , hormone
A 31‐year‐old man, cook, who had had persistent watery diarrhea for about a month visited our hospital. He had already been diagnosed as having pachydermoperiostosis. An examination of the upper gastrointestinal tract revealed that he had giant gastric rugae. The histology was compatible with hypertrophic gastritis accompanied with marked hyperplasia of the fundic gland and foveolar epithelia. The output of gastric juice was high in volume, although its acidity normal. The barium transit time of the small intestine was reduced to 15 minutes. His diarrhea was, thus, considered to be induced by gastrointestinal hyperfunction. The patient's glucose tolerance was abnormal and basal Cortisol secretion level was high. Pachydermoperiostosis has been the focus of attention for skin and bone changes, and the frequency of this disease with endocrine disorders seems rather high, but accompanying gastrointestinal disorders have so far not often been reported in Japan. The results of our investigation strongly suggest that pachydermoperiostosis is a systemic disease.