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Gastric Cancer Developing in a Patient with Chronic Lymphocytic Leukemia with Massive Gastrointestinal Involvement
Author(s) -
MATSUHASHI Nobuyuki,
URABE Akio,
OHNISHI Shin,
OHNISHI Mayumi,
KONDO Yukio,
SUGANO Kentaro,
TAKAKU Fumimaro
Publication year - 1990
Publication title -
digestive endoscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.5
H-Index - 56
eISSN - 1443-1661
pISSN - 0915-5635
DOI - 10.1111/j.1443-1661.1990.tb00069.x
Subject(s) - medicine , stomach , chronic lymphocytic leukemia , gastrointestinal cancer , duodenum , cancer , pathology , esophagus , gastroenterology , leukemia , colorectal cancer
Massive infiltration of neoplastic lymphocytes caused a variety of gross gastrointestinal manifestations in a 71‐year‐old patient with chronic lymphocytic leukemia (CLL). These included plaque‐like elevations in the esophagus, convoluted gyrus‐like folds in the stomach, and many polypoid lesions in the stomach and duodenum. No gross lesions were noted in the large intestine. Four years later, systemic chemotherapy reduced the gastrointestinal involvement, but a papillary elevation grew at the gastric angle, which was shown to be an early cancer on histological examination. Gastrointestinal involvement in CLL and second cancers associated with CLL are reviewed, with special reference to the possible relationship between CLL and gastric cancer.