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Genome‐wide association studies in the hunt for genes causing primary open‐angle glaucoma: a review
Author(s) -
Burdon Kathryn P
Publication year - 2012
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2011.02744.x
Subject(s) - open angle glaucoma , glaucoma , genome wide association study , medicine , genetic association , normal tension glaucoma , ophthalmology , genome , optic disc , genetics , gene , optometry , bioinformatics , genotype , biology , single nucleotide polymorphism
A bstract Genome‐wide association studies are a powerful tool for the identification of genetic risk factors for complex disease. This methodology has been successfully applied to primary open‐angle glaucoma through the analysis of primary open‐angle glaucoma (POAG) as well as specific subgroups of patients including those with normal tension glaucoma and advanced glaucoma. In addition, the analysis of quantitative traits important in POAG, including optic disc area and vertical cup‐to‐disc ratio has also identified genes important in POAG development. This review explores findings of genome‐wide association studies for POAG and related traits.