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Translational neuroprotection research in glaucoma: a review of definitions and principles
Author(s) -
Casson Robert J,
Chidlow Glyn,
Ebneter Andreas,
Wood John PM,
Crowston Jonathan,
Goldberg Ivan
Publication year - 2011
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2011.02563.x
Subject(s) - medicine , glaucoma , blindness , neuroprotection , modalities , intensive care medicine , intraocular pressure , treatment modality , neuroscience , optometry , ophthalmology , surgery , pharmacology , social science , sociology , biology
A bstract The maintenance of vision, through prevention and attenuation of neuronal injury in glaucoma, forms the basis of current clinical practice. Currently, the reduction of intraocular pressure is the only proven method to achieve these goals. Although this strategy enjoys considerable success, some patients progress to blindness; hence, additional management options are highly desirable. Several terms describing treatment modalities of neuronal diseases with potential applicability to glaucoma are used in the literature, including neuroprotection , neurorecovery , neurorescue and neuroregeneration . These phenomena have not been defined within a coherent framework. Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic.