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Vascular risk factors in glaucoma: a review
Author(s) -
Yanagi Masahide,
Kawasaki Ryo,
Wang Jie Jin,
Wong Tien Y,
Crowston Jonathan,
Kiuchi Yoshiaki
Publication year - 2011
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2010.02455.x
Subject(s) - medicine , glaucoma , intraocular pressure , ophthalmology , pathogenesis , ocular hypertension , optic neuropathy , risk factor , open angle glaucoma , blindness , diabetes mellitus , optic nerve , optometry , endocrinology
A bstract Glaucoma, one of the major causes of blindness in the world, is a progressive optic neuropathy. Elevated intraocular pressure is a well‐known major risk factor for glaucoma. In addition, there is growing evidence that vascular factors may play a role in glaucoma pathogenesis. Systemic (e.g. hypertension, diabetes) and ocular vascular factors (e.g. ocular blood flow, ocular perfusion pressure) have been assessed for associations with glaucoma. However, direct and convincing evidence for primary mechanisms of glaucoma is still lacking. The aim of this review is to summarize the evidence implicating vascular factors in the pathogenesis of glaucoma, with particular emphasis on the role of ocular blood flow and ocular circulation as risk factors for primary open angle glaucoma.