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New era for personalized medicine: the diagnosis and management of age‐related macular degeneration
Author(s) -
Baird Paul N,
Hageman Gregory S,
Guymer Robyn H
Publication year - 2009
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2009.02136.x
Subject(s) - medicine , macular degeneration , disease , personalized medicine , etiology , degeneration (medical) , trait , intensive care medicine , risk analysis (engineering) , bioinformatics , optometry , pathology , ophthalmology , computer science , biology , programming language
A bstract It can be argued that age‐related macular degeneration is one of the best characterized complex trait diseases. Extensive information related to genetic and environmental risk factors exists, and a number of different biological pathways are strongly implicated in its aetiology. Along with recent improvements in high throughput and relatively inexpensive genetic technologies, we are now in a position to consider developing a presymptomatic, personalized approach towards the assessment, management and treatment of this disease. We explore the applicability and challenges of this approach if it is to become commonplace for guiding treatment decisions for individuals with pre‐existing disease or for those at high risk of developing it.