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Optic perineuritis secondary to Wegener's granulomatosis
Author(s) -
Purvin Valerie,
Kawasaki Aki
Publication year - 2009
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2009.02122.x
Subject(s) - medicine , prednisone , respiratory tract , dermatology , medical record , surgery , respiratory system
A bstract Background: Optic perineuritis (OPN) is an inflammatory condition involving the optic nerve sheath because of a variety of causes. We describe three patients in whom OPN was secondary to Wegener's granulomatosis (WG) and compare the clinical findings in these cases with those of idiopathic OPN. Methods: This is a retrospective small case series derived from patients with OPN seen in an outpatient neuro‐ophthalmology clinic. Medical records and imaging studies of these patients were reviewed. Results: These patients shared clinical similarities with idiopathic OPN including age, sex, symptoms, radiographic findings and steroid responsiveness. However, recurrence of symptoms on lowering the prednisone dose below 40 mg distinguished these patients from those with idiopathic OPN. Conclusions: Steroid dependency in idiopathic OPN should raise suspicion of WG. Patients with OPN should be specifically questioned regarding pre‐existing upper respiratory tract disorders and rheumatic symptoms and laboratory testing should include acute phase reactants, anti‐neutrophil cytoplasmic antibodies and tests of renal function.