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Comparison of the effect of intracameral moxifloxacin, levofloxacin and cefazolin on rabbit corneal endothelial cells
Author(s) -
Kim SuYoung,
Park YoungHoon,
Lee YoungChun
Publication year - 2008
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2008.01771.x
Subject(s) - moxifloxacin , cefazolin , medicine , balanced salt solution , corneal endothelium , levofloxacin , ophthalmology , cornea , antibiotics , microbiology and biotechnology , chemistry , biology , organic chemistry
A bstract Purpose: To compare the effect on corneal endothelial cells among intracameral moxifloxacin, levofloxacin and cefazoline in rabbits. Methods: Thirty‐six eyes from eighteen rabbits were divided into four groups. The control solution (balanced salt solution), cefazolin 1000 µg/0.1 mL, levofloxain 500 µg/0.1 mL or moxifloxacin 500 µg/0.1 mL was injected into the anterior chamber of the rabbit eye. The central corneal thickness was assessed before the injection of intracameral antibiotics. Endothelial toxicity was evaluated according to the central corneal thickness, specular microscopy, scanning electron microscopy and transmission electron microscopy 1 day after injection. Results: Before the injection, the central corneal thickness was not different among four groups. After injection, there was no significant difference of the corneal thickness and endothelial cell count between the control and study groups. The central corneal thickness after injection of antibiotics did not significantly change when compared with control. Scanning electron microscopy showed normal hexagonality. Normal architecture of the endothelial cells was noted in transmission electron microscopy in all four groups. Conclusions: Intracameral injection of antibiotics (cefazolin 1000 µg/0.1 mL, levofloxain 500 µg/0.1 mL, moxifloxacin 500 µg/0.1 mL) did not show significant toxicity on the endothelial cells compared with the control group. Intracameral injection of one of these antibiotics appears to be safe for surgical prophylaxis.