Premium
Free Papers
Author(s) -
Cheung, Ning,
Klein, Ronald,
Wang, Jie-Jin,
Cotch, Mary-Frances,
Islam, Amirul,
Klein, Barbara,
Cushman, Mary
Publication year - 2008
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2008.01745.x
Subject(s) - medicine , citation , library science , information retrieval , computer science
Purpose: To describe the prevalence of retinal vein occlusion (RVO) in a multi-ethnic cohort and examine its associations with traditional and novel cardiovascular risk factors. Method: A population-based, cross-sectional study of 6,147 participants (whites, blacks, Hispanics, Chinese) from 6 U.S. communities. RVO cases were identified from retinal photographs taken from both eyes using a non-mydriatic retinal camera following a standardized protocol. Participants had a comprehensive standardized cardiovascular examination. Results: The prevalence of RVO was 1.1% (0.9% for branch RVO and 0.2% for central RVO). The prevalence rates were similar across different ethnic groups: 0.9% in whites, 1.2% in blacks, 1.2% in Hispanics and 1.1% in Chinese (p = 0.76). After adjusting for age, gender and ethnicity, RVO was associated with hypertension (odds ratio [OR] 2.32; 95% confidence interval [CI]: 1.34, 4.01), systolic (OR 1.53; 95% CI: 1.21, 1.92, per standard deviation increase) and diastolic (OR 1.71; 95% CI: 1.35, 2.17, per standard deviation increase) blood pressure, elevated serum creatinine (OR 1.21; 95% CI: 1.05, 1.39, per standard deviation increase), hypertriglyceridemia (OR 2.07; 95% CI: 1.17, 3.69), hyperhomocysteinemia (OR 1.88; 95% CI: 1.04, 3.41), mild (OR 2.23; 95% CI: 1.28, 3.88) and moderate-severe (OR 3.73; 95% CI: 1.57, 8.88) renal dysfunction, arteriovenous nicking (OR 5.71; 95% CI: 3.04, 10.7) and focal arteriolar narrowing (OR 6.35; 95% CI: 2.17, 18.6). In multivariate analysis, the associations of RVO with hypertension, hypertriglyceridemia, renal dysfunction, retinal arteriovenous nicking and focal arteriolar narrowing remained significant. RVO was not significantly associated with diabetes, smoking, atherosclerotic measures and circulating markers of inflammation, coagulation and endothelial dysfunction. Conclusion: The prevalence of RVO is similar across four different ethnic populations. RVO is associated with a range of traditional and novel systemic and retinal vascular risk factors