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Cyclosporin effectively inhibits posterior capsule opacification after phacoemulsification in rabbits: a preliminary study
Author(s) -
Totan Yüksel,
Yağcı Ramazan,
Erdurmuş Mesut,
Bayrak Reyhan,
Hepşen İbrahim Feyzi
Publication year - 2008
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2007.01653.x
Subject(s) - medicine , phacoemulsification , posterior capsule opacification , capsule , ophthalmology , cataract surgery , surgery , visual acuity , botany , biology
A bstract Purpose: To evaluate whether cyclosporin A prevents or reduce posterior capsule opacification after phacoemulsification surgery in rabbit eyes. Methods: Twenty rabbits underwent cataract surgery in their right eyes were randomized into two groups. In group 1, 0.1 mL cyclosporin A (0.5 mg/mL) was given into the capsular bag after phacoemulsification and 0.1 mL cyclosporin A (0.5 mg/mL) was injected subconjunctivally once every 3 days for 1 week. Group 2 served as a control group. The development of posterior capsule opacification was assessed weekly, its density was graded clinically, and the proliferation of lens epithelial cells was evaluated histologically. Results: On clinical assessment, cyclosporin A was significantly effective in preventing posterior capsule opacification compared with controls ( P = 0.0045). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment group, in contrast to multilayer lens epithelial cells proliferation in the control group. Conclusion: The preliminary results indicate that cyclosporin A is effective in suppressing posterior capsule opacification in rabbits, yet requires further investigation.