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Comparison of posterior capsule opacification in rabbits receiving either mitomycin‐C or distilled water for sealed‐capsule irrigation during cataract surgery
Author(s) -
Kim SuYoung,
Kim JinHyung,
Choi JunSub,
Joo ChounKi
Publication year - 2007
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2007.01588.x
Subject(s) - medicine , capsule , phacoemulsification , mitomycin c , balanced salt solution , distilled water , cataract surgery , posterior capsule opacification , surgery , toxicity , ophthalmology , anesthesia , visual acuity , chemistry , botany , organic chemistry , chromatography , biology
A bstract Purpose: To compare posterior capsule opacification (PCO) in rabbits who undergo cataract surgery and receive either mitomycin‐C (MMC) or distilled water (DW) during sealed‐capsule irrigation (SCI). In addition, we examined the toxicity of DW and MMC. Methods: Twenty‐four eyes from 12 rabbits were divided into three groups. Balanced salt solution (BSS), DW, MMC 0.4 mg/mL was injected into the capsular bag for 2 min after endocapsular phacoemulsification and insertion of a SCI device. The degree of PCO was assessed by POCOman software at 3 months post surgery. Central corneal thickness, anterior chamber inflammation were assessed 1 day, 1 week, 2 weeks, 3 weeks, 1 month and 3 months postoperatively. Results: A statistically significant difference in PCO scores was noted between the control and study groups ( P < 0.05). The PCO scores of the MMC group were significantly lower than those of the DW group ( P < 0.05). The MMC and DW groups did not show significant toxicity compared with the BSS group. Conclusions: MMC is more effective in reducing PCO than DW; the SCI device can protect the surrounding ocular tissue from MMC toxicity in rabbit eyes.