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Erythropoietin levels in aqueous humour in eyes with exudative age‐related macular degeneration and diabetic retinopathy
Author(s) -
Jonas Jost B,
Neumaier Michael
Publication year - 2007
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2006.01437.x
Subject(s) - medicine , macular degeneration , erythropoietin , diabetic retinopathy , ophthalmology , triamcinolone acetonide , retinopathy , diabetes mellitus , endocrinology
A bstract The purpose of this study was to evaluate whether the concentration of erythropoietin as another potent ischemia‐induced angiogenic factor is elevated in eyes with neovascular (age‐related macular degeneration [AMD]) or oedematous (diabetic retinopathy) maculopathies. The clinical comparative study included 28 patients with diabetic macular oedema, 59 patients with exudative AMD, and 49 patients with cataract. For all patients, aqueous humour was collected during cataract surgery or during an intravitreal injection of triamcinolone acetonide. Erythropoietin levels were measured using a solid‐phase chemiluminescence immunoassay. The mean concentration of erythropoietin was significantly higher in the diabetic group (60.1 ± 46.7 mUnits/mL; P < 0.001) than in the age‐related macular degeneration group (22.9 ± 23.2 mUnits/mL) and in the control group (22.0 ± 21.0 mUnits/mL; P < 0.001). The two latter groups did not vary significantly ( P = 0.41). The results indicate that erythropoietin may be present in considerably higher concentrations in eyes with diabetic macular oedema than in eyes with exudative AMD or normal eyes.