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Negative electroretinograms in pericentral pigmentary retinal degeneration
Author(s) -
Hotta Kazuki,
Kondo Mineo,
Nakamura Makoto,
Hotta Junko,
Terasaki Hiroko,
Miyake Yozo,
Hida Tetsuo
Publication year - 2006
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2006.01127.x
Subject(s) - electroretinography , electrophysiology , medicine , erg , ophthalmology , retinal , retinal degeneration , retina , audiology , neuroscience , biology
A bstract The clinical presentation and electrophysiological findings are described of three consecutive cases with pericentral pigmentary retinal degeneration. The responses to bright flashes after dark adaptation showed negative waveform shape in all cases. Rod responses were strongly reduced compared with cone responses. Cone electroretinograms elicited by long‐duration stimuli showed greater loss of the on‐response than the off‐response. The ratio of the on‐response amplitude to off‐response amplitude of these patients (0.52 ± 0.12; mean ± SD, n = 6) was significantly smaller than that of normal subject (0.83 ± 0.21; mean ± SD, n = 8) (Mann–Whitney U ‐test, P < 0.01). The electrophysiological findings of these cases suggest a greater defect of inner retinal function, especially in transmission between photoreceptors and depolarizing bipolar cells.