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Primary treatment of choroidal amelanotic melanoma with photodynamic therapy
Author(s) -
Donaldson Mark J,
Lim Lyndell,
Harper C Alex,
Mackenzie John,
G Campbell William
Publication year - 2005
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2005.01083.x
Subject(s) - verteporfin , medicine , photodynamic therapy , choroidal melanoma , amelanotic melanoma , melanoma , radiation therapy , brachytherapy , optic neuropathy , dermatology , surgery , ophthalmology , optic nerve , visual acuity , choroidal neovascularization , cancer research , chemistry , organic chemistry
A bstract The management of choroidal melanoma involves a delicate balance between preserving vision and preventing metastasis. Plaque brachytherapy has become standard management of most small lesions; however, this can result in radiation retinopathy and optic neuropathy. Transpupillary thermotherapy avoids these side‐effects; however, it can also result in visual loss and its effectiveness is limited in amelanotic lesions. Photodynamic therapy with verteporfin has shown promise in animal studies of choroidal melanoma, and has recently been used in the management of lesions that have failed to respond to conventional therapy. The authors report a case of primary treatment of a small choroidal amelanotic melanoma with photodynamic therapy using verteporfin.