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Stretch‐activated channels: a mini‐review. Are stretch‐activated channels an ocular barometer?
Author(s) -
Kalapesi Freny B,
Tan James CH,
Coroneo Minas T
Publication year - 2005
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2005.00981.x
Subject(s) - medicine , barometer , neuroscience , biology , quantum mechanics , physics
All cells are subject to physical forces by virtue of their position in a dynamically changing environment. This review outlines the various putative ‘mechanosensors’, or sensors of pressure cells possess, and discusses in particular the role stretch‐activated membrane channels play in pressure recognition and transduction. The widespread occurrence of these channels is discussed and these ‘mechanosensors’ are related to pressure‐related diseases, in particular, glaucoma.