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Anti‐GM1 antibodies: the cause of otherwise unexplained ophthalmoplegias?
Author(s) -
Kowal Lionel,
Gajus Michelle Andrea,
Kornberg Andrew J
Publication year - 2004
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2004.00847.x
Subject(s) - medicine , antibody , immunology
Purpose: To report four patients with otherwise unexplained ophthalmoplegia who were found to have elevated levels of anti‐GM1 antibodies. Methods: Retrospective chart evaluation of 50 consecutive patients with otherwise unexplained ophthalmoparesis. All patients were tested for anti‐GM1 antibodies. Results: Six out of 50 cases (12%) were found to have elevated anti‐GM1 antibodies, far greater than the 2.7% found in the general population. Four of the subjects with elevated anti‐GM1 antibodies are reported. Conclusion: Although the mechanism and relationship between the neural antibodies and ophthalmoparesis is not understood, it is proposed that the presence of anti‐GM1 antibodies should be considered in cases of otherwise unexplained ophthalmoplegia.