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Trimethoprim−sulphamethoxazole therapy in Nocardia keratitis
Author(s) -
Kalavathy C Muniswamy,
Parmar Pragya,
Ramalingam MD Kuthalingam,
Kaliamurthy Jayaraman,
Jesudasan CA Nelson,
Thomas Philip A
Publication year - 2004
Publication title -
clinical and experimental ophthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 1442-6404
DOI - 10.1111/j.1442-9071.2004.00816.x
Subject(s) - medicine , nocardia , trimethoprim , keratitis , ciprofloxacin , dermatology , nocardiosis , surgery , antibiotics , microbiology and biotechnology , bacteria , genetics , biology
Purpose: To describe the clinical features, microbiological features and treatment outcome of nine patients with Nocardia keratitis treated with topical trimethoprim− sulphamethoxazole drops. Methods: Retrospective review of nine patients with culture‐proven Nocardia keratitis. Results: Nine patients with Nocardia keratitis were treated with topical trimethoprim−sulphamethoxazole drops. The average duration of treatment was 25 ± 9 days. Five of the nine patients presented with superficial ulcers with margins studded with yellowish white discrete pinhead sized infiltration; the other four patients had deep stromal infiltration. Complete healing of the ulcer was achieved in six out of the nine patients with topical trimethoprim− sulphamethoxazole alone or in combination with ciprofloxacin 0.3% eye drops. Conclusion: Topical application of trimethoprim−sulphamethoxazole appears to be effective therapy for superficial keratitis due to Nocardia .