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IMMUNOLOGICAL FEATURES OF HLA‐B27 ANTERIOR UVEITIS
Author(s) -
FRACP DENIS WAKEFIELD,
BSc JOAN EASTER,
MSC PAUL ROBINSON,
DSC RONALD PENNY
Publication year - 1983
Publication title -
australian journal of opthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 0310-1177
DOI - 10.1111/j.1442-9071.1983.tb01040.x
Subject(s) - hla b27 , anterior uveitis , medicine , human leukocyte antigen , uveitis , immunology , ophthalmology , antigen
Analysis ol the immunological features of anterior Uveitis (AU) revealed a dichotomy of abnormalities defined in terms of the HLA‐B27 status of the patient. HLA‐B27‐positive AU was characterised by the occurrence of ins autoantibodies and an absolute T cell lymphopenia during active disease which returned to normal with recovery. This phenomenon was not observed in HLA‐B27‐negative AU or in controls and could not be attributed to antilymphocyte antibodies as these were not detected. Furthermore, there were no changes in T‐cell subsets (helper and suppressor T lymphocytes). Compared with HLA‐B27‐positive AU patients, the HLA‐B27‐negative group demonstrated elevated lgE levels and increased prevalence of smooth muscle autoantibodies. Key words: anterior Uveitis, HLA‐B27, immunological abnormalities, T lymphocytes, autoantibodies.