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Consideration of Corticosteroid Action in Ophthalmology
Author(s) -
Leopold Irving H.
Publication year - 1977
Publication title -
australian journal of opthalmology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.3
H-Index - 74
eISSN - 1442-9071
pISSN - 0310-1177
DOI - 10.1111/j.1442-9071.1977.tb00240.x
Subject(s) - medicine , corticosteroid , intraocular pressure , uveitis , glaucoma , adrenal cortex hormones , dermatology , anesthesia , ophthalmology , surgery
S ummary C orticosteroids are relatively benign when given in large doses for a few days only but may be associated with severe side effects when administered continuously. Our knowledge of the action of corticosteroids has increased in the past 25 years, e.g., cellular receptors for corticosteroids, effect on blood elements, on intraocular pressure, pseudocholinesterase and drug interactions. The anti‐inflammatory effect of corticosteroids may include membrane stabilization but other actions may be equally important. Some corticosteroids are less likely to induce ocular hypertension and should be given preference when the anti‐inflammatory actions are satisfactory. Combinations of antibiotics and corticosteroids do have a place in ocular therapy. Patients with open angle glaucoma may have an increased sensitivity to topical and systemic steroids. Tests may be performed to determine the proper fashion to withdraw corticosteroid therapy. Allergies and uveitis may be induced by corticosteroids. Pseudocholinesterase values may be depressed by large oral doses of corticosteroids. There are a number of drugs with which the corticosteroids may interact.