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Murine double minute 2 promoter SNP309 polymorphism and prostate cancer risk: A meta‐analysis
Author(s) -
Liu Guoyuan,
Jiang Deke,
Shen Suqin,
Yu Long
Publication year - 2012
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2012.03067.x
Subject(s) - odds ratio , confidence interval , prostate cancer , medicine , allele , genetic model , meta analysis , single nucleotide polymorphism , oncology , prostate , carcinogenesis , gastroenterology , genotype , cancer , gene , genetics , biology
Objective: The murine double minute 2 gene encodes a negative regulator of the tumor protein p53. A single nucleotide polymorphism in murine double minute 2 promoter, SNP309 T>G, has been reported to alter murine double minute 2 protein expression and to accelerate tumor formation in humans. We carried out a meta‐analysis to explore the association between this polymorphism and prostate cancer risk. Methods: All eligible studies were searched in PubMed. Crude odds ratios, with 95% confidence intervals, were assessed for the association using fixed‐ and random‐effects models. Results: Overall, five case–control studies (872 cases, 1005 controls) were included in the meta‐analysis. A significant association between murine double minute 2 SNP309 and prostate cancer risk was observed for homozygote genetic model GG versus TT (odds ratio 0.72, 95% confidence interval 0.55–0.95, P < 0.05, P = 0.130 for heterogeneity), and for dominant model TG + GG versus TT (odds ratio 0.79, 95% confidence interval 0.65–0.96, P < 0.05, P = 0.119 for heterogeneity). The stratified analysis based on ethnicity showed a significant effect of the polymorphism on prostate cancer risk in Caucasians for GG versus TT. Conclusions: Findings of the present meta‐analysis suggest that the murine double minute 2 309 G allele might be associated with a reduced risk of prostate cancer. The effect of murine double minute 2 309 G allele on tumorigenesis might be influenced by sex and hormonal status.