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Poorly differentiated neuroendocrine carcinoma of the seminal vesicle
Author(s) -
Yasunaga Yutaka,
Ueda Takafumi,
Kodama Yoshinori,
Oka Toshitsugu
Publication year - 2012
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2011.02944.x
Subject(s) - medicine , neuroendocrine differentiation , seminal vesicle , synaptophysin , chromogranin a , pathology , enolase , carcinoma , metastasis , etoposide , adenocarcinoma , prostate , prostate cancer , cancer , immunohistochemistry , chemotherapy
We describe an extremely rare case of poorly differentiated neuroendocrine carcinoma arising from the seminal vesicle. A 67‐year‐old man presented with a left humeral bone tumor resulting in a pathological fracture. Positron emission tomography scan disclosed a large pelvic tumor mimicking prostatic cancer invading into the seminal vesicle. Laboratory data showed an elevation of neuron‐specific enolase, despite the normal prostate‐specific antigen. Transrectal needle biopsy showed a poorly differentiated carcinoma of the right seminal vesicle and the metastasis of the pelvic lymph node. Immunohistochemical results were compatible with the features of neuroendocrine carcinoma; synaptophysin, chromogranin A and CD 56 were positive. The previously biopsied bone tumor was finally diagnosed as a metastasis. A systemic chemotherapy using etoposide and cisplatin failed. The patient died of cancer one‐and‐a‐half years later.