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Mercaptoacetyltriglycine‐3 renogram is not superior to estimated glomerular filtration rate measurement for the prediction of long‐term renal function after nephrectomy
Author(s) -
Kanamaru Hiroshi,
Yamamoto Masakazu,
Nagahama Kanji,
Yagihashi Yusuke,
Kato Keiji,
Oida Tomoyuki,
Kannno Toru,
Takao Noriyasu,
Shimizu Yusuke,
Shichiri Yasumasa
Publication year - 2011
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2011.02791.x
Subject(s) - medicine , renal function , effective renal plasma flow , nephrectomy , urology , kidney disease , creatinine , logistic regression , univariate analysis , kidney , radioisotope renography , stage (stratigraphy) , multivariate analysis , renal blood flow , paleontology , biology
Objective: To evaluate the clinical usefulness of effective renal plasma flow (ERPF) measured using preoperative mercaptoacetyltriglycine‐3 (MAG3) renogram for the prediction of chronic renal insufficiency after nephrectomy. Methods: A total of 47 patients underwent preoperative MAG3 renal scintigraphy and subsequent unilateral nephrectomy. Correlations between the 5‐year postoperative estimated glomerular filtration rate (eGFR) and the preoperative ERPF of the contralateral kidney (cERPF), ERPF of the diseased kidney (dERPF), total ERPF (tERPF), cERPF to dERPF ratio, serum creatinine (sCr) level, eGFR, as well as the influence of preoperative comorbidities (diabetes, hypertension) on the postoperative eGFR, were evaluated with both univariate and multivariate analyses. Results: Multiple linear regression analysis showed that preoperative cERPF significantly correlated with postoperative eGFR. However, a much stronger correlation was observed between the preoperative and postoperative eGFR. Multiple logistic regression analysis showed that only preoperative eGFR was a significant predicator of the development of advanced‐stage chronic kidney disease (CKD). Conclusions: Preoperative MAG3 renogram is not superior to eGFR measurement as a prognostic indicator of long‐term renal function after unilateral nephrectomy.