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Harmful gases including carcinogens produced during transurethral resection of the prostate and vaporization
Author(s) -
Chung Yun Jo,
Lee Sang Kyi,
Han Suk Hee,
Zhao Chen,
Kim Myung Ki,
Park Seung Chul,
Park Jong Kwan
Publication year - 2010
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2010.02636.x
Subject(s) - vaporization , acrylonitrile , acetylene , smoke , medicine , chromatography , chemistry , organic chemistry , copolymer , polymer
Objective: To determine the chemical composition of surgical smoke produced during transurethral resection of the prostate (TURP) and vaporization. Methods: A total of 12 smoke samples were collected from a continuous irrigation suction drainage system to a Tenax absorber at a 0.05 L/min flow rate during TURP and vaporization. The gases were quantitatively and qualitatively analyzed by gas chromatography‐mass spectrometry (GC‐MS) equipped with a purge and trap sample injector. Results: The main chemical constituents of surgical smoke produced during TURP and vaporization include propylene, allene, isobutylene, 1,3‐butadiene, vinyl acetylene, mecaptomethane, ethyl acetylene, diacetylene, 1‐pentene, EtOH, piperylene, propenylacetylene, 1,4‐pentadiene, cyclopentadiene, acrylnitrile and butyrolactone. Three of the constituents are very toxic and carcinogenic (1,3‐butadiene, vinyl acetylene and acrylonitrile). The amount (mean ± standard deviation) of chemical components in the 45 L of gas and room air mixture produced during TURP and vaporization were as follows: propylene, 0.80 ± 0.52 mg; isobutylene, 212.85 ± 75.65 mg; 1,3‐butadiene, 0.93 ± 0.34 mg; ethyl acetylene, 0.09 ± 0.05 mg; 1‐pentene, 6.75 ± 1.62 mg; 1,4‐pentadiene, 0.06 ± 0.02 mg; and acrylonitrile, 1.62 ± 1.19 mg. Conclusions: Three of the toxic gases generated during TURP and vaporization are carcinogens (1,3‐butadiene, vinyl acetylene and acrylonitrile). Therefore, higher quality filter masks, smoke evacuation devices and/or smoke filters should be developed for the safety of the operating room personnel and patients during TURP and vaporization.