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Inhibitions of urinary oxidative stress and renal calcium level by an extract of Quercus salicina Blume/ Quercus stenophylla Makino in a rat calcium oxalate urolithiasis model
Author(s) -
Moriyama Manabu T,
Suga Koudai,
Miyazawa Katsuhito,
Tanaka Tatsuro,
Higashioka Masaya,
Noda Kumiko,
Oka Michiko,
Tanaka Mitsushi,
Suzuki Koji
Publication year - 2009
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2009.02268.x
Subject(s) - malondialdehyde , calcium oxalate , medicine , oxidative stress , calcium , oxalate , renal stone , pharmacology , traditional medicine , urinary system , chemistry , organic chemistry
Objectives: To clarify the mechanism of Urocalun, an extract of Quercus salicina Blume /Quercus stenophylla Makino (QS), in the treatment of urolithiasis. Methods: Rat calcium oxalate urolithiasis was induced by oral administration of ethylene glycol and the vitamin D 3 analog alfa‐calcidol for 14 days. QS extract was repeatedly given to rats. After the last administration, biochemistries in urine and plasma, renal calcium, and urinary malondialdehyde (an oxidative stress marker) were measured. Results: Ethylene glycol and alfa‐calcidol treatment increased urinary malondialdehyde and renal calcium levels. This increase was significantly suppressed by the administration of QS extract, suggesting that the inhibition of renal calcium accumulation by QS extract is due to its antioxidative activity. Conclusions: These findings suggest that the antioxidative activity of QS extract plays a role in the prevention of stone formation and recurrence in urolithiasis.