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Primary large cell neuroendocrine carcinoma of the urinary bladder
Author(s) -
Akamatsu Shusuke,
Kanamaru Sojun,
Ishihara Misa,
Sano Takeshi,
Soeda Asaki,
Hashimoto Kimio
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2008.02168.x
Subject(s) - medicine , cystoprostatectomy , cystoscopy , urinary bladder , pathology , small cell carcinoma , carcinoma , neuroendocrine carcinoma , urinary system , urology , bladder cancer , cancer , cystectomy
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder is rare. It is a type of neuroendocrine carcinoma morphologically distinct from small cell carcinoma. We report here a case of primary LCNEC of the urinary bladder. We observed a very large invasive tumor, which was not able to be detected three months previously by cystoscopy or computed tomography. The tumor cells morphologically and immunohistochemically resembled that of pulmonary LCNEC. With prompt cystoprostatectomy and chemotherapy, the patient is free of disease 16 months after diagnosis. Although LCNEC is usually very aggressive, it may be controlled by early diagnosis and treatment.