Premium
Ejaculatory dysfunction caused by the new α 1 ‐blocker silodosin: A preliminary study to analyze human ejaculation using color Doppler ultrasonography
Author(s) -
Nagai Atsushi,
Hara Ryoei,
Yokoyama Teruhiko,
Jo Yoshimasa,
Fujii Tomohiro,
Miyaji Yoshiyuki
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2008.02136.x
Subject(s) - medicine , silodosin , ejaculation , doppler effect , ultrasonography , urology , color doppler , gynecology , radiology , prostate , astronomy , lower urinary tract symptoms , cancer , physics
Objectives: In order to clinically investigate the mechanism of ejaculatory dysfunction attributable to the α 1 ‐blocker silodosin, a real‐time observation of ejaculation by healthy males was performed. Methods: Following intake of silodosin, a newly developed selective α 1 ‐blocker for benign prostatic hypertrophy, ejaculation was dynamically observed using color Doppler ultrasound in three healthy males. Normal ejaculation was also investigated in the same manner. Results: With silodosin intake, no antegrade ejaculation was observed in cases 1 or 2. In case 1, seminal fluid slowly but continuously flowed out from the seminal vesicles into the bladder. In case 2, only a small amount of seminal fluid flowed into the bladder during the ejaculatory sensation. In case 3, ejection of a small amount of semen from the external urethral orifice was observed and inflow of a small amount of seminal fluid into the bladder was also captured. Without silodosin intake, all three subjects exhibited antegrade ejaculation. Conclusions: The mechanism of ejaculatory dysfunction is intricately related to retrograde ejaculation (retrograde inflow of seminal fluid), insufficient contraction of the seminal vesicles, and insufficient rhythmic contraction of the muscles of the pelvic floor.