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Clinical Effect of alpha 1D/A adrenoceptor inhibitor naftopidil on Benign Prostatic Hyperplasia: An International Prostate Symptom Score and King's Health Questionnaire assessment
Author(s) -
Awa Yusuke,
Suzuki Hiroyoshi,
Hamano Satoshi,
Okano Tatsuya,
Sakurayama Yuri,
Ohki Takemasa,
Egoshi Kenichi,
Ota Sho,
Mori Ikuo,
Ichikawa Tomohiko
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2008.02097.x
Subject(s) - medicine , international prostate symptom score , lower urinary tract symptoms , urology , overactive bladder , quality of life (healthcare) , hyperplasia , prostate , benign prostatic hyperplasia (bph) , gynecology , nursing , alternative medicine , pathology , cancer
Objectives: To examine the effect of alpha 1D/A adrenoceptor inhibitor naftopidil on health‐related quality of life (QOL) in men with benign prostatic hyperplasia (BPH). Methods: A total of 56 newly diagnosed patients with symptomatic BPH were prospectively enrolled and treated with 50 mg naftopidil daily for more than 12 weeks. All underwent pre‐treatment documentation of lower urinary tract symptoms, QOL assessment using the international prostate symptom score (IPSS) and King's Health Questionnaire (KHQ), and uroflowmetry. A post‐treatment assessment was performed at 12 weeks. Results: IPSS scores as well as QOL index showed a significant improvement after naftopidil administration. Similarly, all seven domains except general health perceptions and social limitations in the KHQ questionnaire were significantly improved. When dividing the patients into overactive bladder (OAB) and non‐OAB groups, only the OAB group showed significant improvement in almost all the domains of KHQ. Change ratios of the IPSS were not associated with those of KHQ domain scores in the OAB group. On the other hand, in the non‐OAB group more domains presented improvements, which were associated with those of IPSS scores. Conclusions: Twelve‐week treatment with naftopidil for symptomatic BPH patients is associated with significant improvement in the IPSS, QOL index, maximum urinary flow rate, post‐void residual urine volume (PVR) and almost all domains in KHQ. KHQ is useful for the evaluation of clinical response in BPH patients, particularly in those with associated OAB.