Premium
Prostate stem cells: The niche and cell markers
Author(s) -
Takao Tetsuya,
Tsujimura Akira
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2008.02047.x
Subject(s) - stem cell , prostate cancer , prostate , medicine , stem cell niche , hyperplasia , niche , prostate diseases , pathology , biology , cancer , progenitor cell , microbiology and biotechnology , ecology
Prostate cancer and benign prostatic hyperplasia are common diseases in elderly men worldwide. Identifying the prostate stem cell is an important tool to investigate the mechanism of these prostatic diseases. Although the prostate stem cell has not yet been detected, progress has been made. The ‘niche’ or place in which the prostate stem cell resides is thought to be located in the proximal region of the murine prostate, near the urethra. Several candidate prostate stem cell markers are currently under investigation. In this review, we summarize the historical approaches and recent evidence regarding the niche and prostate‐specific stem cell markers.