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Loxoprofen sodium treatment for elderly men with refractory nocturia: Effect on night‐time urine production
Author(s) -
Okada Shinsuke,
Watanabe Hideki,
Kojima Yoshiyuki,
Yanai Yoshimasa,
Sasaki Shoichi,
Kohri Kenjiro
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2008.02021.x
Subject(s) - nocturia , medicine , urine , refractory (planetary science) , urology , sodium , urine sodium , urinary system , chemistry , physics , organic chemistry , astrobiology
Abstract: We evaluated the efficacy of loxoprofen sodium for refractory nocturia. Twelve men (mean age, 75.1 ± 5.7) with nocturia were enrolled in this study. All patients received 60 mg loxoprofen sodium prior to sleeping at night for 14 days. Nine of 12 patients (75%) felt more satisfaction than previous treatments. Patients were grouped into a loxoprofen sodium‐effective ( n = 7) and ineffective groups ( n = 5) based on the results of the frequency‐volume chart. In the effective group, interestingly, night‐time urine volume showed significant reduction ( P < 0.05). On the other hand, the average single voided volume at night and 24‐h urine volume showed no significant change. There was a statistically significant difference in the night‐time urine volume after treatment between groups ( P < 0.01). Loxoprofen sodium is an effective treatment for some patients with refractory nocturia. The main effect mechanism of loxoprofen sodium may involve the reduction of night‐time urine production.