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α 1 ‐Adrenoceptor subtypes and lower urinary tract symptoms
Author(s) -
Schwinn Debra A,
Roehrborn Claus G
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2007.01956.x
Subject(s) - medicine , lower urinary tract symptoms , urology , hyperplasia , prostate , urinary system , bladder outlet obstruction , clinical trial , cancer
Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in aging men leading to lower urinary tract symptoms (LUTS). α 1 ‐Adrenoceptors (α 1 ARs) antagonists (blockers) have become a mainstay of LUTS treatment because they relax prostate smooth muscle and decrease urethral resistance, as well as relieving bladder LUTS symptoms. A review of key recent clinical trials suggests new insights into the role of specific α 1 AR subtypes in the treatment of LUTS.