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Genetic variants of the cytochrome P450 and glutathione S‐transferase associated with risk of bladder cancer in a south‐eastern Chinese population
Author(s) -
Shao Jianfeng,
Gu Min,
Zhang Zhendong,
Xu Zhuoqun,
Hu Qiang,
Qian Lixin
Publication year - 2008
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2007.01915.x
Subject(s) - bladder cancer , odds ratio , medicine , genotype , gastroenterology , confidence interval , case control study , restriction fragment length polymorphism , glutathione s transferase , oncology , population , cancer , genetics , glutathione , gene , biology , biochemistry , enzyme , environmental health
Objective: To evaluate the association between genetic polymorphisms of CYP2E1 RsaI and GSTM1 and development of bladder cancer in a south‐eastern Han Chinese population. Methods: We hypothesized that the CYP2E1 ‐1019T>A and GSTM1 polymorphisms were associated with risk of bladder cancer. In a hospital‐based case‐control study of 202 case patients with newly diagnosed bladder transitional cell carcinoma and 272 cancer‐free controls frequency‐matched by the age and sex, we genotyped these two polymorphisms using a polymerase chain reaction‐restriction fragment length polymorphism method. Results: We found that the GSTM1 null genotype was associated with an increased risk of bladder cancer (adjusted odds ratio [OR] = 1.73, 95% confidence interval [CI] = 1.17–2.56) compared with those with the non‐null genotype, but the CYP2E1 ‐1019T>A polymorphisms did not show any association. In the stratification analysis of the GSTM1 polymorphism, we found that the increased risk was more pronounced among subgroups aged ≤60 years (OR = 2.02, 95% CI = 1.08–3.77), smokers (OR = 1.94, 95% CI = 1.11–3.38) and non‐drinkers (OR = 3.86, 95% CI = 1.28–11.60). Conclusion: GSTM1 polymorphism (but not CYP2E1 RsaI polymorphism) appears to contribute to the etiology of bladder cancer in a south‐eastern Chinese population.