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Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients: Preliminary study
Author(s) -
Satoh Shigeru,
Saito Mitsuru,
Inoue Kazuyuki,
Miura Masatomo,
Komatsuda Atsushi,
Habuchi Tomonori
Publication year - 2007
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2007.01886.x
Subject(s) - medicine , subclinical infection , immunosuppression , chronic allograft nephropathy , univariate analysis , gastroenterology , transplantation , tacrolimus , renal function , nephropathy , genotype , creatinine , immunology , kidney transplantation , endocrinology , multivariate analysis , diabetes mellitus , biochemistry , chemistry , gene
Background: The present study calculated the risk of developing subclinical progressive chronic/sclerosing allograft nephropathy (CAN) under tacrolimus‐based immunosuppression according to genetic polymorphisms of cytokines and growth factors, and clinical events including delayed graft function (DGF), acute rejection (AR) and cytomegalovirus (CMV) infection. Methods: The subjects were 50 recipients with stable graft function more than one year after renal transplantation. The criteria for subclinical progressive CAN were CAN grade 2 or 3 changes on Banff classification and stable serum creatinine (SCr) levels. Ten genetic polymorphisms were assessed. Results: Eleven patients (22.0%) developed progressive CAN. The mean ages and SCr levels of recipients with and without progressive CAN were 41.2 and 47.1 years, and 1.46 and 1.22 mg/dL, respectively. There were no significant differences in donor age, number of HLA mismatches, DGF or CMV infection. Although the rate of AR episode seemed to be greater in patients with subclinical progressive CAN, the difference did not reach significance ( P = 0.093). The frequencies of the interleukin ( IL ) ‐2 T‐330G TT genotype ( P = 0.046) and IL‐4 C‐590T C allele ( P = 0.092) were higher in patients with progressive CAN. In univariate analysis, the presence of IL‐2 T‐330G TT (OR 4.57, P = 0.044) was associated with CAN development. Conclusion: The presence of IL‐2 T‐330G TT genotype may be a risk factor for CAN. Further studies with a large number of subjects and analyses of many cytokine polymorphisms would contribute to the ability to make prognostic determinations or tailor immunomodulatory regimens after renal transplantation.