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Renal transplantation after myeloablative and non‐myeloablative hematopoietic cell transplantation from the same donor
Author(s) -
Tanaka Toshiaki,
Ishida Hideki,
Shirakawa Hiroki,
Amano Hiroyuki,
Nishida Hayato,
Tanabe Kazunari
Publication year - 2007
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2007.01877.x
Subject(s) - medicine , transplantation , hematopoietic stem cell transplantation , regimen , haematopoiesis , hematopoietic cell , conditioning regimen , bone marrow , stem cell , surgery , biology , genetics
Hematopoietic cell transplantation is a key treatment to prolong patient survival for many hematological disorders. Renal impairment is well recognized as a significant complication of hematopoietic cell transplantation, which can progress to end‐stage renal disease. Herein, we report our experience of two patients who underwent renal transplantation from the same donor who provided cells for the preceding hematopoietic cell transplantation. One patient had undergone peripheral blood stem cell transplantation with a non‐myeloablative conditioning regimen, whereas the other had received bone marrow transplantation with a myeloablative regimen. Chronic immunosuppressive therapy was not needed in either one to maintain the kidney graft function. Not only bone marrow transplantation with a myeloablative conditioning regimen, but also peripheral blood stem cell transplantation with a non‐myeloablative regimen can confer immunological tolerance.