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The participation of adenosine receptors in the adenosine 5′‐triphosphate‐induced relaxation in the isolated rabbit corpus cavernosum penis
Author(s) -
Kataoka Kazuyoshi,
Furukawa Katsuo,
Nagao Kohichi,
Ishii Nobuhisa,
Tsuru Hiromichi
Publication year - 2007
Publication title -
international journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.172
H-Index - 67
eISSN - 1442-2042
pISSN - 0919-8172
DOI - 10.1111/j.1442-2042.2007.01803.x
Subject(s) - adenosine , caffeine , adenosine triphosphate , medicine , adenosine receptor , adenosine a1 receptor , endocrinology , adenosine a2b receptor , purinergic signalling , receptor , antagonist , penis , adenosine receptor antagonist , relaxation (psychology) , agonist , anatomy
Aim: To investigate the participation of adenosine receptors in the adenosine 5′‐triphosphate (ATP)‐induced relaxation in the corpus cavernosum penis (CCP) of rabbits. Methods: The ATP‐induced relaxation was assessed on the noradrenaline precontracted CCP of rabbits in the presence and absence of 8‐(3‐chlorostyryl)caffeine (CSC); an adenosine A 2A receptor antagonist; alloxazine and MRS1754; adenosine A 2B receptor antagonists; and ARL67156, an inhibitor of ecto‐nucleoside triphosphate diphosphohydrolases. Results: Adenosine and ATP relaxed the noradrenaline precontracted CCP of rabbits in a concentration‐dependent manner. The adenosine‐ and ATP‐induced relaxations were suppressed by alloxazine and MRS1754, but not by 8‐(3‐chlorostyryl)caffeine. ARL67156 potentiated the ATP‐induced relaxation but not the adenosine‐induced one. MRS1754 suppressed the ATP‐induced relaxation potentiated by ARL67156. Conclusions: The above results suggest that, in the CCP of rabbits, the adenosine receptor mediating adenosine‐induced relaxation is of the A 2B receptor and the ATP directly causes relaxation through the A 2B receptor on the CCP.